Chromium Polynicotinate is a more biologically active component than other forms of Chromium. CP helps to control blood sugar levels and can be dangerous to the blend of fats, cholesterol, and proteins. It is helpful in the metabolism of glucose and is important for getting energy. Chromium polynicotinate is a mineral that adds a hormone-like regulation to develop carbohydrate metabolism. As all carbohydrates finally are reduced to simple glucose in the body. Chromium polynicotinate provides the mediator action by plugging serum glucose through the bloodstream to the muscle cell directly. Chromium is essential for glucose regulation, carbohydrate metabolism, and energy production. It may also produce anabolic effects, but with no side effects.

Garcinia Cambogia, which is used for the active ingredient, Hydrocitric Acid or HCA. It is extracted from the garcinia cambogia fruit, similar to an orange. It is commonly used as an appetite suppressant. Hydrocitric acid or HCA is a "lipogenesis inhibitor," which means that it slows down the production of fat from the metabolism of carbohydrates and proteins. This means that more calories are burned as energy and less are turned into stored fat. Studies on animals and humans have shown that HCA can suppress fat production and reduce appetite.

Guarana is a climbing plant of the Sapindaceae family native to the Amazon basin. Guarana is best known for its fruit and seeds. Guarana extracts contain naturally high amounts of caffeine which the plant uses in defense against pathogens. Its extracts are a natural and abundant source of caffeine in most parts of the world. It is added to soft drinks, herbal tea, energy shots and used in capsules. The extracts have a positive effect on cognition and they also increase memory retention and physical endurance. A 2007 study on human pilots showed its positive effects on memory, alertness and mood. It is also reported to have antioxidant and antibacterial effects.

Hoodia Gordonii grows in Namibia and South Africa naturally. It is a leafless spiny plant useful for medicinal purposes. These flowers are pollinated by flies mainly as they smell identical to rotten meat. Hoodia is known long by indigenous population and is infrequently used for treating small infections and indigestion. This is used to suppress appetite during long hunting trips such as Kalahari Desert that interests more tourists. Hoodia Gordonii was prominent for it appetite suppressing effect and hence was collaborated with Pfizer, a pharmaceutical company to deal with obesity. However, it was stopped as it is stated to have indications of effects on liver. Hoodia Gordonii is wild harvested by individuals as well as by few companies that are granted license. However, there is no evidence of Hoodia working in humans as appetite suppressant. Due to the lack of clarity and fear of breaking down of liver, it is not recommended for obesity.

Synthetic Guggulsterones is naturally found in the resin of the guggul plant, it is a plant sterol and the Latin name of the plant is Commiphora mukul. It is believed that in humans, an extract of the guggul plant functions as a farnesoid X receptor inhibitor, theoretically attributing to a diminished synthesis of cholesterol in the liver. It is a very popular nutritional supplement and exists in several synthetic variants which are popular with the body building communities. The most popular application is the one as a weight loss agent, but it has been observed that Synthetic Guggulsterones may also stimulate thyroid function directly. While there is a debate if synthetic or natural guggulsterones are to be preferred, the availability and price of Synthetic Guggulsterones is currently prevailing.